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Background Coronary microembolization(CME) is characterized by distal microvascular occlusion. However, the inflammatory mechanisms and therapeutic targets of CME are largely unknown. Methods A total of 11 Guangxi Bama miniature swines were divided into two groups: sham(n = 5) and CME(n = 6). Microspheres were injected into the left anterior descending artery of the CME group to make an animal model of CME. The expressions of micro RNA-146a(miR-146a) and IRAK1, TRAF6, and AUF1 in the myocardium were detected by q PCR. Results In the CME group, microspheres, microinfarction, and inflammatory cell infiltration were found under an optical microscope. The expression levels of miR-146 a were low in both groups. After CME, the expression levels of IRAK1, TRAF6, and AUF1 in the CME group were upregulated compared with those in the sham group(P < 0.01;P < 0.05;P < 0.05, respectively). Conclusions AUF1, IRAK1 and TRAF6, but not miR-146 a,could be involved, in myocardium inflammation following CME.
However, the inflammatory mechanisms and therapeutic targets of CME are largely unknown. Methods A total of 11 Guangxi Bama miniature swines were divided into two groups: sham (n = 5) and CME (n = 6). Microspheres were injected into the left anterior descending artery of the CME group to make an animal model of CME. The expressions of microRNA-146a (miR-146a) and IRAK1, TRAF6, and AUF1 in the myocardium were detected by q PCR. Results In the CME group, microspheres, microinfarction, and inflammatory cell infiltration were found under an optical microscope. The expression levels of miR-146 a were low in both groups. After CME, the expression levels of IRAK1, TRAF6 , and AUF1 in the CME group were upregulated compared with those in the sham group (P <0.01; P <0.05, respectively). Conclusions AUF1, IRAK1 and TRAF6, but not miR- in myocardium inflammation following C ME.