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本文用小剂量人白细胞干扰素治疗慢性乙型肝炎及病毒携带者20例,疗程3个月,HB_sAg 滴度几何平均值从治疗前1∶97.01±3.74下降为1∶11.5±3.28,P<0.001,有极显著意义,其中 HB_sAg 转阴13例占65%;HB_eAg 阳性7例治疗后6例转阴占85.7%;HB_cAg 阳性3例治疗后都转阴占100%。对照组(聚肌胞)20例治疗前后,3个抗原改变不显著,其结果表明,小剂量人白细胞干扰素治疗乙型肝炎有初步效果。
In this paper, a small dose of human leukocyte interferon treatment of chronic hepatitis B and virus carriers in 20 cases, the course of 3 months, HBsAg titers geometric mean decreased from 1: 97.01 ± 3.74 before treatment to 1: 11.5 ± 3.28, P <0.001 , Of which there was a significant difference. Of them, 13 cases of negative HBsAg accounted for 65%; 6 cases of positive HB_eAg after treatment were negative for 85.7%; and 3 cases for HBcAg positive were negative for 100% after treatment. The control group (polymyositis) 20 patients before and after treatment, the three antigens did not change significantly, the results show that small doses of human leukocyte interferon in the treatment of hepatitis B have a preliminary effect.