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目的探讨高血脂患者血清血管粘附蛋白-1(VAP-1)表达水平及其间的相互影响。方法选择高血脂患者,检测血清血脂各指标水平,同时检测VAP-1表达水平,并以正常人血清进行比较。结果 TG、CH及VAP-1在两组间有统计学差异,高血脂组中,TG、CH与LDL、ApoB、VAP-1相关均有相关关系。结论高血脂人群合并VAP-1升高,而VAP-1的升高则是高血脂患者心脑血管疾病发生的重要环节。
Objective To investigate the expression of serum vascular adhesion protein-1 (VAP-1) in patients with hyperlipidemia and its interaction. Methods Patients with hyperlipidemia were selected, serum lipid levels were measured, VAP-1 expression levels were measured and compared with normal human serum. Results TG, CH and VAP-1 were significantly different between the two groups. In hyperlipidemia group, TG, CH were correlated with LDL, ApoB and VAP-1. Conclusions Hyperlipidemia is associated with an increase in VAP-1, while an increase in VAP-1 is an important link in the development of cardiovascular and cerebrovascular diseases in hyperlipidemic patients.