神经生长因子（NGF）是神经元的发育分化所必需的因子，推测神经母细胞瘤可能为神经母细胞分化过程中受到阻滞的结果。本研究以18个人神经母细胞瘤细胞系为基本材料研究了NGF诱导分化规律结果发现：NGF诱导瘤细胞分化与NGF受体的有无，N－myc癌基因的扩增或过度表达及瘤细胞的 Nerve growth factor (NGF) is an essential factor for the development and differentiation of neurons. It is speculated that neuroblastoma may be the result of blockage during the process of neuroblast differentiation. In this study, 18 human neuroblastoma cell lines were used as basic materials to study the NGF-induced differentiation. Results: NGF induced differentiation of tumor cells and the presence or absence of NGF receptors, amplification or overexpression of N-myc oncogenes, and tumor cells of