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沙海葵毒素(Palytoxin)是从海洋Palythoa属的腔肠动物所得的一个剧毒的、水溶性物质。它是Polyketide,而不是多醣或多肽。除天然高分子化合物外,它是分子最大和最复杂的化合物之一。其毒性远远超过河豚毒素和海藻毒素。它对动物具有独特的生物作用,例如具有强烈的血管收缩和冠状痉挛作用。鼠的腹腔注射半致死量(LD_(50))是0.4微克/公斤。双键氢化后或用0.1NNaOH处理后,其毒性完全消失。美国Moore是研究夏威夷(Hawaiian)Palythoa toxica和大溪地(Tahiti)p.sp.的。日本Hirata是研究冲绳岛(Okinawa)的P.tuberculose的。两国化学家几乎都经历
Palytoxin is a virulent, water-soluble substance obtained from the coelenterate of the genus Palythoa of the ocean. It is Polyketide, not polysaccharide or polypeptide. In addition to natural polymer compounds, it is one of the largest and most complex compounds. Its toxicity far more than tetrodotoxin and seaweed toxins. It has unique biological effects on animals, such as strong vasoconstriction and coronary spasm. The median lethal dose (LD 50) of mice injected intraperitoneally was 0.4 μg / kg. After double bond hydrogenation or treatment with 0.1N NaOH, its toxicity completely disappeared. Moore, the United States, studies Palythoa toxica and Tahiti p.sp. In Hawaii. Japan Hirata is P. tuberculose who studies Okinawa. Almost all chemists in both countries have experienced