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目的：研究支气管肺炎时超氧化物歧化酶（ＳＯＤ）、过氧化氢酶（ＣＡＴ）、谷胱甘肽过氧化物酶（ＧＳＨＰＸ）的动态变化及相关性，以探讨其临床意义。方法：检测５２例支气管肺炎患儿极期与恢复期血ＳＯＤ、ＣＡＴ、ＧＳＨＰＸ、丙二醛（ＭＤＡ）活性，设正常对照组６０例。结果：支气管肺炎极期ＳＯＤ、ＣＡＴ、ＧＳＨＰＸ均明显降低，ＭＤＡ显著升高，与正常对照组比较差异非常显著；恢复期ＳＯＤ、ＣＡＴ、ＧＳＨＰＸ均明显上升，ＭＤＡ明显下降，与极期比较差异非常显著。肺炎组极期和恢复期三种抗氧化酶之间均无相关性。结论：支气管肺炎时体内产生过多氧自由基，抗氧化酶ＳＯＤ、ＣＡＴ、ＧＳＨＰＸ活力均下降。测定抗氧化酶可判断病情及预后。此三种抗氧化酶之间关系复杂，统计学上无相关性。以上为治疗中联合应用抗氧化剂提供了理论依据。
Objective: To investigate the dynamic changes and correlations of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHPX) in bronchopneumonia and to explore its clinical significance. Methods: The levels of SOD, CAT, GSHPX and malondialdehyde (MDA) in 52 patients with bronchopneumonia were detected during the period of convalescence and convalescence. 60 patients in normal control group were enrolled. Results: The levels of SOD, CAT and GSHPX in the period of bronchopneumonia were significantly lower than those in the control group (P <0.05). The levels of SOD, CAT and GSHPX in the recovery stage were significantly increased, while the levels of MDA were significantly decreased Significant. There was no correlation between the three antioxidant enzymes in the period of convalescence and convalescence of pneumonia group. CONCLUSION: Excessive oxygen free radicals are produced in bronchoalveolar pneumonia, and the activities of antioxidant enzymes SOD, CAT and GSHPX are decreased. Determination of antioxidant enzymes can determine the condition and prognosis. The relationship between these three antioxidant enzymes is complex and statistically unrelated. The above combination of antioxidants provides a theoretical basis for treatment.