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[目的]探讨冀东非小细胞肺癌患者中表皮生长因子受体(EGFR)的突变情况及其与临床特征间的关系。[方法 ]收集80例非小细胞肺癌患者采用Real-time PCR扩增法检测EGFR的突变情况。[结果 ]80例非小细胞肺癌样本中,女性EGFR突变率明显高于男性(P<0.05);腺癌患者EGFR突变率明显高于其他两种非小细胞肺癌患者(P<0.05);无吸烟史患者EGFR突变率明显高于有吸烟史患者(P<0.05);满族患者EGFR突变率明显高于汉族患者(P<0.05)。[结论]在非小细胞肺癌中,女性EGFR基因的突变率高于男性;不吸烟患者突变率高于吸烟患者;较鳞癌和大细胞癌,腺癌最容易发生突变;满族突变率高于汉族。而且无论是满族还是汉族,没有发现EGFR基因外显子19缺失突变和EGFR外显子21的L858R错义突变间差异。
[Objective] To investigate the mutation of epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer and its relationship with clinical features in eastern Hebei. [Method] 80 cases of non-small cell lung cancer patients were collected to detect the mutation of EGFR by Real-time PCR amplification. [Results] The mutation rates of EGFR in female samples were significantly higher than those in male samples (P <0.05). The mutation rate of EGFR in patients with adenocarcinoma was significantly higher than that in the other two non-small cell lung cancer patients (P <0.05). The mutation rate of EGFR in smokers was significantly higher than that in smokers (P <0.05). The rate of EGFR mutation in Manchu patients was significantly higher than that in Han patients (P <0.05). [Conclusion] The mutation rate of EGFR gene in women is higher than that of men in non-small cell lung cancer. The mutation rate of non-smoking patients is higher than that of smokers. The mutation rate of adenocarcinoma is most easily than squamous cell carcinoma and large cell carcinoma. The mutation rate of Manchu is higher than Han nationality. And whether Manchu or Han, did not find EGFR gene exon 19 deletion mutation and EGFR exon 21 L858R missense mutation difference.