为了降低硝硫氰胺和吡喹酮的毒副反应,提高其疗效,我们将两种药物减量,合并治疗小白鼠血吸虫病,并检测其对小白鼠的急性半数致死量。疗效实验作了两批,分别用小白鼠180只和144只。每批实验分9组,合并用药方式及药物剂量分组如下:第1组,第1日给硝硫氰胺5mg/kg,第2日给吡喹酮150mg/kg;第2组,第1日给吡喹150mg/kg,第2日给 In order to reduce the toxic side effects of nitinamides and praziquantel and improve their curative effect, we reduced the two drugs and combined them to treat schistosomiasis in mice and detected their acute lethal dose to mice. Efficacy experiments were made in two batches, respectively, 180 and 144 mice. Each batch of experiments was divided into 9 groups, the combination of drug and drug dosage groups are as follows: Group 1, the first day to nitrocytamine 5mg / kg, the first two days to praziquantel 150mg / kg; Group 2, the first day To pirarubic 150mg / kg, on the 2nd to give