HIV/SIV攻击宿主免疫系统,导致获得性免疫缺陷综合征。一旦这些慢病毒建立系统性感染,宿主的免疫系统很难有效控制病毒复制。然而,在粘膜暴露后的最初几天里,即感染建立的最初阶段,病毒大量复制及全身播散之前,病毒比较脆弱而容易控制。Scott G.Hansen等人用恒河猴巨细胞病毒(RhCMV)作为载体 HIV / SIV attacks the host immune system, resulting in acquired immunodeficiency syndrome. Once these lentiviruses establish a systemic infection, it is difficult for the host’s immune system to effectively control viral replication. However, the virus is relatively fragile and easy to control until the first few days after mucosal exposure, ie during the initial stages of infection, after extensive virus replication and systemic dissemination. Scott G. Hansen et al. Used rhesus cytomegalovirus (RhCMV) as a vector