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目的比较国产米格列奈和进口那格列奈治疗2型糖尿病的疗效和安全性。方法用随机双盲双模拟平行方法,244例患者经国产米格列奈或进口那格列奈16周治疗,比较两组糖化血红蛋白(HbA1c)、餐后2 h血糖(2hPBG)、空腹血糖(FBG)降低情况。结果两组治疗后HbA1c、2hPBG和FBG均较治疗前显著降低,两组自身比较差异有统计学意义(P<0.05),两组治疗前后的差值组间比较差异无统计学意义(P>0.05)。HbA1c达标率、静脉2hPBG、FBG控制情况两组类似,差异无统计学意义(P>0.05)。两组不良事件发生率之间差异均无统计学意义(P>0.05)。结论国产米格列奈片治疗2型糖尿病疗效确切,安全性和耐受性良好。
Objective To compare the efficacy and safety of domestic mitiglinide and imported nateglinide in the treatment of type 2 diabetes mellitus. Methods 244 cases were treated with domestic mitiglinide or nateglinide for 16 weeks. The levels of HbA1c, 2hPBG and fasting blood glucose (FBG) were compared between the two groups. FBG) to reduce the situation. Results After treatment, HbA1c, 2hPBG and FBG in both groups were significantly lower than those before treatment, there was significant difference between the two groups (P <0.05). There was no significant difference between the two groups before and after treatment (P> 0.05). HbA1c compliance rate, venous 2hPBG, FBG control similar to the two groups, the difference was not statistically significant (P> 0.05). There was no significant difference between the two groups in the incidence of adverse events (P> 0.05). Conclusion The domestic application of mitochondrial tablets in the treatment of type 2 diabetes is effective, safe and well tolerated.