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目的了解上海某妇产科医院药品不良反应(ADR)发生的特点及规律,探讨临床药师对妇产专科患者用药监护的要点,提高临床合理用药水平。方法对该院收集的189例ADR报告按患者年龄、药品种类、ADR累及器官/系统及临床表现等进行统计分析。结果 ADR涉及的药品中抗感染药居于首位;ADR最常见的临床表现为皮肤及其附件损害;发生严重ADR的药品中以抗肿瘤药居多;40周岁以上住院患者ADR发生例数明显多于门诊。结论临床药师应重点监护抗感染药、抗肿瘤药等高致敏性药品;对住院人群,尤其是妇产科、过敏性体质等特殊人群用药应重点监护。
Objective To understand the characteristics and rules of adverse drug reaction (ADR) in a gynecological hospital in Shanghai and to discuss the main points of clinical pharmacists’ monitoring on medication in patients with obstetrics and gynecology, and to improve the clinical reasonable medication level. Methods A total of 189 ADR cases collected in this hospital were analyzed according to patient’s age, drug type, ADR involved organ / system and clinical manifestations. Results ADR was the first anti-infective drug among the drugs involved. ADR was the most common clinical manifestation of skin and its accessory damage. Anti-tumor drugs were predominant in those with serious ADR. The incidence of ADR in hospitalized patients over 40 years old was significantly higher than that of outpatients . Conclusion Clinical pharmacists should focus on the monitoring of anti-infectives, anti-tumor drugs and other highly sensitized drugs; for inpatients, especially obstetrics and gynecology, allergic constitution and other special populations medication should focus on custody.