细胞毒性T淋巴细胞相关性抗原4是已知最重要的免疫抑制性受体，该基因的基因多态性与支气管哮喘发病密切相关，其融合蛋白能有效抑制哮喘动物模型的气道高反应性、肺部嗜酸粒细胞增多等表现，使抗原导致的气道功能紊乱症状明显减轻，对将来应用于临床提供了广阔前景。 Cytotoxic T lymphocyte-associated antigen 4 is the most important known immunosuppressive receptor. The genetic polymorphism of this gene is closely related to the pathogenesis of bronchial asthma. Its fusion protein can effectively inhibit the airway hyperresponsiveness in the animal model of asthma , Pulmonary eosinophilia and other performance, so that antigen-induced airway dysfunction significantly reduced symptoms, the future for clinical application provides a broad prospect.