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目的研究老年支气管哮喘病人周围血CD4+CD45RO+T细胞表达IL-4及IL-13的情况及CTLA4-Ig对其影响。方法用ELISA方法测定老年支气管哮喘病人CD4+CD45RO+T细胞产生IL-4和IL-13的水平及CTLA4-Ig对其影响。结果老年支气管哮喘病人CD4+CD45RO+T细胞分泌IL-4、IL-13增多,IL-13增多较IL-4更为明显(P<0.01),CTLA4-Ig可有效抑制老年哮喘病人CD4+CD45RO+T细胞分泌IL-4和IL-13(P<0.01)。结论CD4+CD45RO+T细胞产生的IL-4和IL-13在老年哮喘发病中起重要作用,CTLA4-Ig可有效抑制IL-4和IL-13的分泌。
Objective To study the expression of IL-4 and IL-13 in CD4 + CD45RO + T cells in elderly patients with bronchial asthma and the effect of CTLA4-Ig on it. Methods The levels of IL-4 and IL-13 produced by CD4 + CD45RO + T cells in elderly patients with bronchial asthma and the effect of CTLA4-Ig on them were determined by ELISA. Results The levels of IL-4 and IL-13 in CD4 + CD45RO + T cells in elderly patients with bronchial asthma increased, IL-13 increased more significantly than those in IL-4, and CTLA4-Ig could effectively inhibit CD4 + CD45RO + T cells secrete IL-4 and IL-13 (P <0.01). Conclusion IL-4 and IL-13 produced by CD4 + CD45RO + T cells play an important role in the pathogenesis of senile asthma. CTLA4-Ig can effectively inhibit the secretion of IL-4 and IL-13.