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目的研究人类免疫缺陷病毒(HIV)感染者和获得性免疫缺陷综合症(AIDS)患者CD4+T淋巴细胞数变化(ΔCD4+T)和外周血淋巴细胞总数变化(ΔTLC)的相关性。探讨用ΔTLC预测ΔCD4+T在监测HIV/AIDS患者疾病进展以及高效抗逆转录病毒治疗(HAART)疗效的价值。方法回顾性分析20052008年确诊的91例HIV/AIDS患者的临床资料。结果ΔTLC与ΔCD4+T呈直线正相关(r=0.809,P<0.01),好于TLC与CD4+T的相关性(r=0.712,P<0.01)。分别用ΔTLC170、330、630、910个/μL细胞预测ΔCD4+T50、100、200、300个/μL细胞时具有较好的预测价值,各项评价指标符合率基本达到90%以上,显著高于相同时间下用TLC预测CD4+T计数的价值。结论应用ΔTLC预测ΔCD4+T,可比TLC更加直观、准确的反映HIV感染者疾病进展和评价AIDS患者HAART的疗效。
Objective To study the correlation between CD4 + T lymphocyte number (ΔCD4 + T) and total peripheral blood lymphocyte (ΔTLC) in patients with human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS). To explore the value of ΔTLC in predicting the progress of ΔCD4 + T in the monitoring of disease progression in patients with HIV / AIDS and the efficacy of highly active antiretroviral therapy (HAART). Methods The clinical data of 91 HIV / AIDS patients confirmed in 2005-2008 were retrospectively analyzed. Results ΔTLC was positively correlated with ΔCD4 + T (r = 0.809, P <0.01), which was better than that of TLC with CD4 + T (r = 0.712, P <0.01). The predictive value ofΔCD4 + T50, 100, 200, 300 cells / μL cells withΔTLC170, 330, 630 and 910 cells / μL cells respectively, the coincidence rate of each evaluation index reached more than 90%, which was significantly higher than The value of CD4 + T count was predicted by TLC at the same time. Conclusion Using ΔTLC to predict ΔCD4 + T can be more direct and accurate than TLC to reflect the disease progression in HIV-infected patients and evaluate the efficacy of HAART in AIDS patients.