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嗜肺军团菌通过其特有的Dot/Icm type-IVB分泌系统向宿主胞内分泌多种效应因子,有效俘获了宿主胞内参与囊泡转运的重要蛋白,从而“绑架”了宿主细胞的囊泡运输过程,达到逃避宿主清除机制并大量增殖的目的。这些效应因子包括Sid M、Lid A、Lep B、Ank X、Lem3、Sid D、Ral F、Vip D等,通过对这些效应因子的鉴定、功能试验和结构生物学研究,逐渐揭示了它们较为完整深入的分子作用机制。本文综述了目前已知的参与调控宿主囊泡转运过程的重要效应因子及其空间结构和分子机制,有助于综合了解这种复杂的病原微生物与宿主相互作用的过程。
Legionella pneumophila secrete a variety of effector cells into the host cells through its unique Dot / Icm type-IVB secretion system, which effectively captures the important proteins involved in vesicle transport in the host cells, thereby “kidnapping” the host cells’ Bubble transport process, to avoid the host clearance mechanism and a large number of proliferation purposes. These effectors include Sid M, Lid A, Lep B, Ank X, Lem3, Sid D, Ral F, Vip D and so on. Through the identification of these effect factors, functional tests and structural biology studies, they gradually revealed that they are more complete In-depth molecular mechanism of action. This review summarizes the important effect factors and their spatial structure and molecular mechanisms that are currently known to participate in the regulation of host vesicle transport and help to understand the process of the interaction between this complex pathogenic microorganism and the host.