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采用转铁蛋白受体（ＴｆＲ）放射配体结合分析法及红细胞内外铁染色检查，对４１例中期孕（１６～２８孕周）胎肝幼红细胞ＴｆＲ及红细胞内外铁进行了研究。结果发现：①在孕母铁状况正常情况下，胎肝有一定数量的细胞内外铁存在，但明显较成人为少。随着孕母缺铁性贫血（ＩＤＡ）程度的加重，胎肝中红细胞外铁贮存减少，中度ＩＤＡ时几乎全部消失（等级相关ｒ＝一０．５５，Ｐ＝０．００６１）。胎肝红细胞内铁的变化与胎肝红细胞外铁变化趋势相同（ｒ分别一０．４８及一０．５５，Ｐ分别为０．００９及０．００６）。②对胎肝幼红细胞的ＴｆＲ的研究发现，隐性缺铁的孕母，其胎儿肝脏ＴｆＲ与正常无明显差异，但ＩＤＡ母亲的上述ＴｆＲ位点数明显高于正常组（Ｐ均＜０．０５），提示胎儿因铁代谢受到影响而出现了相应代偿性变化。上述结果提示，中期孕母亲患缺铁性贫血对胎儿肝脏铁代谢有直接的不良影响。
TfR and erythrocyte extracellular and extracellular iron of 41 fetal metaplasia (16 ~ 28 gestational weeks) fetuses were studied by TfR radioligand binding assay and red blood cell internal and external iron staining. The results showed that: ① In the normal condition of pregnant mother’s iron, fetal liver has a certain amount of intracellular and extracellular iron, but significantly less than that of adults. As the level of IDA increased, fetal extrahepatic extracellular iron storage was reduced and disappeared at moderate IDA (rank correlation = 0.55, P = 0.0061). The changes of iron in fetal liver red blood cells were the same as those of fetal liver red blood cells (r = 0.48 and 0.55, respectively, p = 0.009 and 0.006, respectively). ② The TfR of fetal liver erythrocytes found that there was no significant difference in the TfR of fetal liver between the pregnant and non-pregnant women, but the number of TfR loci in IDA mothers was significantly higher than that of the normal group (all P <0.05 ), Suggesting that the fetus due to the impact of iron metabolism and the emergence of the corresponding compensatory changes. The above results suggest that mid-term pregnant women suffering from iron deficiency anemia on the iron metabolism of the fetus has a direct adverse effect.