论文部分内容阅读
肾小管性酸中毒(RTA)是肾小管分泌H~+机制紊乱和回收HCO_3-障碍,造成尿液酸化机能失常的临床综合征。可导致慢性代射性酸中毒及电解质紊乱产生低钾血症、软骨病、肾结石等临床症状。自1936年认识RTA来,报道病例并不少见。国内1958年来,陆续有报道,迄今已有100多例。RTA中,以Ⅰ型RTA最为常见,且其生化改变及临床表现比其他类型更为明显。最近国内一组46例RTA的报道中,Ⅰ型RTA占40例。近二十多年来,临床及动物实验对Ⅰ型RTA的发病机理作了广泛的研究,认识有了很大的提高。本文就有关文献作一复习。
Renal tubular acidosis (RTA) is a clinical syndrome of renal tubular secretion H ~ + mechanism disorder and recovery of HCO_3-disorder, resulting in urinary acidosis dysfunction. Can lead to chronic substituting acidosis and electrolyte imbalance hypokalemia, cartilage disease, kidney stones and other clinical symptoms. It is not uncommon to report cases since R36 was known in 1936. Since 1958, there have been reports of more than 100 cases so far. RTA, the most common type Ⅰ RTA, and its biochemical changes and clinical manifestations more obvious than the other types. Recently a group of 46 cases of RTA reports, type I RTA accounted for 40 cases. In the recent twenty years, the clinical and animal experiments have extensively studied the pathogenesis of type I RTA, and the understanding has been greatly improved. This article makes a review of the literature.