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哺乳动物脑内移植已有100年历史了。1890年G·Thompson首次发表了脑移植的文章。早期的研究结果比较混乱,那时的兴趣在于移植神经组织的活存。严格地讲,1970年后才真正出现哺乳动物的脑移植。尤其在近10年内,能将细胞和组织移植到发育中或成年的中枢神经系统(CNS)中去。神经移植已成为一个广泛应用的实验手段。它为分析CNS的功能及功能恢复开辟了一条新的途径,并用于CNS的基础发育及神经元连接的再生研究。一、临床试验及存在问题从许多动物模型得出的结论提示,脑内移植有可能为人类治疗神经退行性疾病提供一种新的治疗措施。脑移植的临床试验是从巴金森氏病开始的。已经证实,人胎儿多巴
Mammalian brain transplantation has been 100 years old. 1890 G · Thompson first published an article on brain transplantation. Early results of the study more confusing, then the interest lies in the survival of transplanted nerve tissue. Strictly speaking, mammalian brain transplantation really occurred after 1970. Especially in the last 10 years, cells and tissues can be transplanted into the developing or adult central nervous system (CNS). Nerve transplantation has become a widely used experimental means. It opens up a new avenue for analyzing the function and function recovery of CNS and is used for the study of the basic development of CNS and the regeneration of neuronal connections. First, the clinical trials and existing problems The conclusions drawn from many animal models suggest that intracerebral transplantation may provide a new therapeutic measure for human treatment of neurodegenerative diseases. Clinical trials of brain transplantation start from Parkinson’s disease. Has confirmed that human fetal dopa