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目的：定量研究ｒａｓｐ２１和突变型ｐ５３基因蛋白在胃癌前病变细胞中的表达，探讨其在癌变机制中的作用以及在胃癌早期诊断的意义。方法：采用胃镜活检和术后胃癌旁残端胃粘膜癌前病变组织８０例，其中不典型增生Ⅰ级２９例，Ⅱ级３０例，Ⅲ级２１例，并取正常胃粘膜１０例?
OBJECTIVE: To quantitatively study the expression of rasp21 and mutant p53 gene in precancerous cells of gastric precancerous lesions and to explore the role of rasp21 and mutant p53 in carcinogenesis and their significance in the early diagnosis of gastric cancer. Methods: Eighty cases of gastric mucosal precancerous lesion with gastric biopsy and gastric cancer were included, including 29 cases with atypical hyperplasia grade Ⅰ, 30 cases with grade Ⅱ, 21 cases with grade Ⅲ, and 10 cases with normal gastric mucosa.