论文部分内容阅读
血卟啉衍生物（即HpD，定位标记为131I-HpD），经小鼠尾静脉注射后，血药浓度下降较快，全身分布迅速广泛，24至32小时变化较为平缓，32小时后几无变化。肺、脾、肝分布较多，肌肉最少，其它组织介于中间，8小时后血液、甲状腺、肺、肝、大腿肌肉等组织呈下降趋势，而肿瘤组织分布相对较多。与其它组织（肺肝除外）相比，具有相对选择性吸收和潴留作用，这种作用在24小时后较为明显。该药72小时内粪排量（57．5％）大于尿排量（42．5％）。血中放射性一时间曲线符合开放二室模型。
Hematoporphyrin derivatives (ie, HpD, the localization marker is 131I-HpD), after injection into the tail vein of mice, the blood drug concentration drops rapidly, and the systemic distribution is rapid and extensive. The changes are relatively flat from 24 to 32 hours, and there are few after 32 hours. Variety. Lungs, spleen and liver were distributed more, muscles were the least, other tissues were in the middle, and blood, thyroid, lung, liver, and thigh muscles and other tissues showed a downward trend after 8 hours, and tumor tissues were relatively more distributed. Compared with other tissues (excluding lung and liver), it has relatively selective absorption and retention, and this effect is more obvious after 24 hours. The discharge of the drug within 72 hours (57.5%) was greater than the urine output (42.5%). The radioactivity-time curve in the blood conforms to the open two-compartment model.