视网膜色素变性是最常见的遗传性致盲眼病之一。近年来通过临床和动物实验发现 :( 1 )不同基因突变引发的RP存在某些共同生化代谢异常 ;( 2 )感光细胞凋亡是各型RP最终通路 ;( 3)在cGMP磷酸二酯酶 β亚单位基因突变导致的RP中 ,钙离子变化与感光细胞变性有密切关系。通过药物干预上述病理过程 ,可以缓解病程进展。本文就近年来维生素A、牛磺酸、二十二碳六烯酸 (DHA)、神经营养因子、钙离子拮抗剂等物质对RP的治疗研究作一介绍。 Retinitis pigmentosa is one of the most common hereditary causes of blindness. In recent years, through clinical and animal experiments found that: (1) mutations caused by different gene mutations in some common biochemical metabolic abnormalities; (2) photoreceptor apoptosis is the final pathway of various types of RP; (3) cGMP phosphodiesterase β RP subunit mutations caused by the changes in calcium and photoreceptor cell degeneration are closely related. Through the intervention of the above pathological processes, the course of disease can be alleviated. In this paper, vitamin A, taurine, docosahexaenoic acid (DHA), neurotrophic factors, calcium antagonists and other substances on the treatment of RP in recent years to make an introduction.