36年前Hufnagel将人工瓣膜移植于降主动脉,完成了首例主动脉瓣替换术。迄今临床上均应用外科手术方法进行心脏瓣膜替换。作者研究的自的在于研制一种可经皮穿刺植入的人工瓣膜,从而避免全麻和心脏直视手术。目前已有10条成年杂种犬用这种方法进行了主动脉瓣植入,并对其设计做了某些改进。作者使用的瓣膜替换物是一种球-笼瓣。整个瓣膜装置可以折叠并通过11F的导管系统,它可自行伸展,一俟被送出导管即自动张开。操作的最后一步是将球瓣放置在笼架中,对该设计 Thirty-six years ago Hufnagel completed the first aortic valve replacement by transplanting artificial valves into the descending aorta. To date, surgical methods have been used to replace heart valves. The author’s research lies in developing a percutaneously implantable prosthetic valve to avoid general anesthesia and open heart surgery. Ten adult mongrel dogs have been aortic valve implantation in this way and some improvements have been made to their design. The valve replacement used by the author is a ball-cage flap. The entire valve device can be folded and passed through the 11F catheter system, which self-expands and opens automatically as soon as it is delivered out of the catheter. The final step in the operation is to place the ball flap in the cage, for this design