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在何杰金氏病(HD)病程中,不同程度的贫血和血小板减少是常见的,但HD伴发特发性血小板减少性紫癜(ITP)和自体免疫性溶血性贫血(AIHA)较为罕见。作者在492例HD病人中发现伴发ITP 5例,伴发AIHA 1例。并复习了文献已报道伴发ITP的33例HD病例。发现HD伴发ITP或AIHA,除了淋巴细胞为主型外,可见于HD的所有组织亚型;能够在HD各期中存在。伴发HD的ITP对细胞毒药物的疗效明显优于原发性ITP。有2例伴发HD的ITP病例发现带状疱疹感染,尚不能断定ITP是由病毒感染所诱发或由于HD免疫调节异常所诱发。在
In the course of Hodgkin’s disease (HD), varying degrees of anemia and thrombocytopenia are common, but HD is associated with rare idiopathic thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AIHA). The authors found in 492 cases of HD patients with ITP in 5 cases, with AIHA in 1 case. And reviewed the literature has reported 33 patients with ITP associated with HD cases. HD associated with ITP or AIHA was found, with the exception of lymphocyte predominance, which is found in all tissue subtypes of HD; can exist in all stages of HD. The efficacy of ITP with HD on cytotoxic agents is significantly better than that of primary ITP. There are two cases of ITP with HD associated with herpes zoster infection, yet I can not conclude that ITP is induced by viral infection or due to abnormal immune regulation of HD induced. in