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作为第二信使的环鸟苷酸(cGMP)在缺氧性肺血管收缩反应(HPV)中的应用,报道很少。有研究显示,亚甲蓝(methylene blue,MB)可通过抑制鸟苷酸环化酶来抑制cGMP的产生。本实验用MB研究cGMP在整体大鼠HPV中的作用。
Cyclic guanylate as a second messenger (cGMP) in hypoxic pulmonary vasoconstriction (HPV) in the application, rarely reported. Studies have shown that methylene blue (MB) inhibits the production of cGMP by inhibiting guanylate cyclase. This study used MB to study the role of cGMP in whole rat HPV.