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细胞凋亡可由辐射、化疗药和其它破坏DNA的制剂所诱导,几种细胞株的证据提示这种诱导是由p53介导的。bcl-2的表达是肿瘤逃避p53介导的凋亡的一种潜在机制。培养细胞中由p53过表达所
Apoptosis can be induced by radiation, chemotherapeutic drugs, and other DNA damaging agents. Evidence from several cell lines suggests that this induction is mediated by p53. The expression of bcl-2 is a potential mechanism by which tumors escape p53-mediated apoptosis. Cultured cells are overexpressed by p53