S(?)zary综合征是一种通常为T淋巴样细胞单克隆增殖造成的少见的、白血病性的皮肤T细胞淋巴瘤(CTCL)。 本文报告1例系双克隆性肿瘤性增殖,并发生严重水肿引起毛细血管渗漏综合征。患者,女性,66岁,因剥脱性皮炎于1990年11月初诊。既往史有胰岛素依赖性糖尿病合并视网膜炎和弥漫性动脉硬化。皮损起于同年夏天,胸前和腋窝处突发的瘙痒性毛囊性苔藓样丘疹,迅速扩散,融合,呈轻度水肿性、剧痒的剥脱性皮炎,查体发现体重减轻,皮损呈弥漫性浸润的亮红色鳞屑性红斑,散在扁平紫色苔藓样丘疹主 S(?)zary syndrome is a rare, leukemic cutaneous T-cell lymphoma (CTCL) that is usually caused by monoclonal proliferation of T lymphoid cells. This article reports 1 case of double clonal neoplastic proliferation and severe edema causing capillary leak syndrome. The patient, female, 66 years old, was newly diagnosed with exfoliative dermatitis in November 1990. The past history of insulin-dependent diabetes mellitus combined with retinitis and diffuse arteriosclerosis. In the summer of the same year, the lesions began in the chest and armpits with sudden itchy hair follicle-like lichenoid papules. They quickly spread and merged. They were mildly edematous, itchy exfoliative dermatitis. Diffuse infiltrated bright red scales erythema, scattered in flat purple moss-like papules