胰岛素抵抗是指正常剂量的胰岛素产生低于正常生物学效应的一种状态,即单位浓度胰岛素的细胞效应减弱。临床上主要表现为由于组织对胰岛素的敏感性下降,代偿性引起胰岛β细胞分泌胰岛素增加而产生的高胰岛素血症。由于胰岛素抵抗是许多内分泌代谢失调相关疾病的共同病理生理基础,而运动可以明显改善胰岛素抵抗,近年来,这一领域的研 Insulin resistance refers to a condition in which normal insulin production is below the normal biological effect, ie, the cellular effect of insulin per unit concentration is diminished. Mainly due to clinical manifestations of insulin sensitivity of the decline, caused by insulin-induced pancreatic β-cell secretion increased hyperinsulinemia. Since insulin resistance is the common pathophysiological basis of many diseases associated with endocrine and metabolic disorders, and exercise can significantly improve insulin resistance, in recent years, research in this field