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本文对40例病人的正常子宫颈上皮以及不同程度的非典型增生和原位癌作了穿刺活检,随后又作了锥形切除术,并进行有丝分裂图象出现的频率的观察和局部(即垂直和横行的)分布情况的研究。从正常的上皮到轻度一中度非典型增生、重度非典型增生直至原位癌,在整个的上皮内有丝分裂出现的频率呈阶梯式的增加。记录了在浅表上皮细胞层内轻度和中度非典型增生之间的有丝分裂图象出现的频率的差异。这些发现支持了子宫颈非典型增生的组织学分类法是正确的。这个初期所报导的各种上皮之间的转化与细胞合成DNA的频率差异有一致的关系。有丝分裂区与无有丝分裂区交替出现甚至支持在此以前自幼放射照相的发现。这说明子宫颈非典型增生和原位癌增生与非增生的上皮区可能共存。《Cancer》39:1218-1223,1977
In this paper, 40 patients with normal cervical epithelium and varying degrees of atypical hyperplasia and carcinoma in situ were biopsied, and then made a conical resection, and mitotic images were observed frequency and local (ie vertical And rampant) distribution of the study. From normal epithelium to mild to moderate atypical hyperplasia, severe atypical hyperplasia to carcinoma in situ, the frequency of mitosis appears to increase stepwise throughout the epithelium. The differences in the frequency of mitotic images between mild and moderate atypical hyperplasia in the superficial epithelial cell layer were recorded. These findings support the histological classification of atypical hyperplasia of the cervix that is correct. The initial report of a variety of epithelial transformation and the frequency of DNA synthesis cells have a consistent relationship. Mitotic and non-mitotic areas alternate or even support the discovery of previous childhood radiographs. This shows that cervical dysplasia and in situ carcinoma hyperplasia and non-hyperplastic epithelial areas may coexist. Cancer 39: 1218-1223,1977