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目的:了解急性脑梗死患者肺炎衣原体(Cpn)感染与血脂、C反应蛋白(CRP)、纤维蛋白原(FIB)的相互关系,探讨其可能的发病机制。方法:应用多聚合酶链反应(PCR)技术检测了100例急性脑梗死患者血清Cpn DNA,选100例非脑梗死患者作为对照组,同时用全自动生化仪检测血脂,免疫透射比浊法检测CRP,凝固法检测FIB。结果:急性脑梗死组Cpn DNA阳性率为68%,对照组Cpn DNA阳性率为38%,两组Cpn DNA阳性率比较差异有显著性(P<0.01)。脑梗死组Cpn阳性患者血脂水平:TC(6.5±1.02)mmol/L,TG(2.11±1.48)mmol/L,LDL-C(3.45±0.46)mmol/L,HDL-C(1.02±0.40)mmol/L;对照组TC,TG,LDL-C,H DL-C水平分别为(4.80±1.12)mmol/L,(1.26±0.42)mmol/L,(3.26±0.45)mmol/L,(1.18±0.26)mmol/L;两组CRP水平分别为:(14.5±7.6)mg/L,(6.8±3.3)mg/L;两组FIB水平分别为:(3.8±0.42)g/L,(2.1±0.28)g/L。两组在血脂、CRP、FIB水平比较差异有显著性。结论:急性脑梗死患者肺炎衣原体感染率明显增高,肺炎衣原体感染可能通过影响血脂代谢来增快动脉粥样硬化,并可能通过炎症反应和凝血功能增强在急性脑梗死的发生、进展中发挥重要作用。
Objective: To investigate the relationship between Cpn infection and blood lipids, C-reactive protein (CRP) and fibrinogen (FIB) in patients with acute cerebral infarction and to explore its possible pathogenesis. Methods: Cpn DNA of 100 patients with acute cerebral infarction was detected by polymerase chain reaction (PCR) and 100 patients with non-cerebral infarction were selected as control group. At the same time, blood lipids were detected by automatic biochemical analyzer, and immunostaining turbidimetric assay CRP, coagulation test FIB. Results: The positive rate of Cpn DNA was 68% in acute cerebral infarction group and 38% in control group. The Cpn DNA positive rate was significantly different between the two groups (P <0.01). The levels of serum lipids in Cpn-positive patients with cerebral infarction were: TC (6.5 ± 1.02) mmol / L, TG 2.11 ± 1.48 mmol / L, LDL-C 3.45 ± 0.46 mmol / L and HDL-C 1.02 ± 0.40 mmol / / L, and the levels of TC, TG, LDL-C and HDL-C in the control group were (4.80 ± 1.12) mmol / L and (1.26 ± 0.42) mmol / L and 0.26) mmol / L; The levels of CRP in the two groups were (14.5 ± 7.6) mg / L and (6.8 ± 3.3) mg / 0.28) g / L. The two groups in the blood fat, CRP, FIB levels were significantly different. Conclusion: The infection rate of Chlamydia pneumoniae in patients with acute cerebral infarction is significantly higher. Chlamydia pneumoniae infection may increase atherosclerosis by affecting blood lipid metabolism and may play an important role in the occurrence and progress of acute cerebral infarction possibly through inflammatory reaction and coagulation enhancement .