脓毒症可产生一种“高动力学状态”,其在肾脏的表现为肾血流增加和肾血管阻力减低。Cronenwett等和本文作者都证明菌血症后肾皮质内血流分布改变,并假定这种改变可能由循环中的前列腺素引起。为阐明这一关系,作者给狗造成大肠杆菌菌血症后,估价前列腺素合成抑制剂消炎痛对肾皮质内肾血流分布和血清前列腺素水平的作用。 Sepsis can produce a “hyperkinetic state” that manifests in the kidneys as increased renal blood flow and reduced renal vascular resistance. Cronenwett et al., And the authors of this paper, have shown that there is a change in the distribution of blood flow within the renal cortex after bacteremia and that this change is presumed to be caused by circulating prostaglandins. To elucidate this relationship, the authors evaluated the effect of the prostaglandin synthesis inhibitor indomethacin on renal renal blood flow distribution and serum prostaglandin levels after causing E. coli bacteremia in dogs.