论文部分内容阅读
[目的]探讨骨桥蛋白与血管内皮生长因子-C在Ⅰa～Ⅱa期宫颈癌中的表达与病理特征的关系及在宫颈癌淋巴结转移中的作用。[方法]运用S-P法检测44例Ⅰa～Ⅱa期宫颈癌组织中骨桥蛋白、血管内皮生长因子-C的水平。[结果]①宫颈癌组织中骨桥蛋白及血管内皮生长因子-C的阳性表达率均高于正常宫颈组织,均与临床分期有关。②骨桥蛋白的表达在小于或等于1个淋巴结转移患者与大于1个淋巴结转移患者比较,差异有统计学意义。③骨桥蛋白与血管内皮生长因子-C在宫颈癌中的表达呈正相关。[结论]骨桥蛋白、血管内皮生长因子-C在宫颈癌中呈阳性表达。二者的阳性表达均与临床分期有关。联合检测可作为筛选宫颈癌高危患者的手段之一。检测宫颈癌组织骨桥蛋白表达可为预测盆腔淋巴结转移提供帮助。
[Objective] To investigate the relationship between the expression of osteopontin and vascular endothelial growth factor-C in stage Ⅰa-Ⅱa cervical cancer and the pathological features and the role in the lymph node metastasis of cervical cancer. [Method] The levels of osteopontin and vascular endothelial growth factor-C in 44 patients with stage Ⅰa-Ⅱa cervical cancer were detected by S-P method. [Results] ① The positive rates of osteopontin and VEGF in cervical cancer tissues were higher than those in normal cervical tissues, all of which were related to clinical stage. ② The expression of osteopontin in patients with less than or equal to 1 lymph node metastasis and more than 1 lymph node metastasis, the difference was statistically significant. ③ osteopontin and VEGF-C expression in cervical cancer was positively correlated. [Conclusion] Osteopontin and Vascular Endothelial Growth Factor-C are positively expressed in cervical cancer. Both positive expression and clinical stage related. Joint detection can be used as a screening method for high-risk patients with cervical cancer. Detection of osteopontin expression in cervical cancer tissue may be helpful in predicting pelvic lymph node metastasis.