作者报道1例29岁男性,患胆囊原发性恶性黑色素瘤,合并急性胆囊炎,继发胆囊穿孔及胆汁性腹膜炎的病例,并进行了文献复习。肉眼见胆囊长9cm,直径3.5cm,在胆囊底部粘膜面有一直径2.5cm 乳头状肿物,组织学诊断恶性黑色素瘤,免疫组化测定S～100蛋白和波形蛋白均阳性,组织中的棕色色素经Masson Hamperl 染色证 The authors reported a case of a 29-year-old man with gallbladder primary malignant melanoma, acute cholecystitis, secondary gallbladder perforation and biliary peritonitis, and reviewed the literature. The naked eye showed a gallbladder length of 9cm, a diameter of 3.5cm, a papillary mass with a diameter of 2.5cm at the mucosal surface of the gallbladder bottom, histological diagnosis of malignant melanoma, immunohistochemical determination of positive S-100 protein and vimentin, and brown pigment in the tissue. Passed Masson Hamperl Dyeing Certificate