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重症肌无力（MG）是神经肌肉传递障碍的自身免疫性疾病,它是以抗乙酰胆碱受体（AchR）抗体为其主要的致病性抗体。目前认为该抗体的产生依赖于T淋巴细胞,T细胞所分泌的细胞因子参与了实验性自身免疫性重症肌无力（EAMG）的诱导和发病过程。干扰素-γ（IFN-γ）和白细胞介素-4（IL-4）分别由Th1和 Th2亚型细胞所分泌,在机体免疫调节中起重要作用。本实验检测了早期发病的MG手术病人的骨髓、胸腺及外周血中IFN-γ和IL-4分泌细胞数,以期了解是否Th1及Th2均参与了MG的发病过程。
Myasthenia gravis (MG) is an autoimmune disease of neuromuscular transmission disorder. It is the major pathogenic antibody with anti-acetylcholine receptor (AchR) antibody. At present, it is thought that the production of this antibody depends on T lymphocytes. The cytokines secreted by T cells are involved in the induction and pathogenesis of experimental autoimmune myasthenia gravis (EAMG). Interferon-γ (IFN-γ) and interleukin-4 (IL-4) are secreted by Th1 and Th2 subtypes, respectively, and play an important role in immune regulation. This experiment examined the early onset of MG surgery in patients with bone marrow, thymus and peripheral blood IFN-γ and IL-4 secretion of cells in order to understand whether Th1 and Th2 are involved in the pathogenesis of MG.