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作者报告1例妊娠所致的严重高血压患者,用Prostacyclin治疗。患者29岁,既往妊娠2次均并发高血压。第一胎因胎儿宫内生长迟缓行剖腹产,第二胎孕14周发生稽留流产。两次妊娠间隔期血压正常。第三次妊娠,于孕10周时血压130/80mmHg,于孕22周血压升至150/90mmHg,给予甲基多巴治疗,开始0.75g/日逐渐增加剂量,妊娠第二十六周出现蛋白尿,第二十七周甲基多巴剂量增至3g/日血压不能控制,又加服肼苯达嗪,剂量加至150mg/日仍不能控制血压。由于常规降压药无效,而给予静脉输入Prostacyclin,开始剂量8μg/kg/分,血压出乎意料的明显下降,舒张压从140mmHg降
The authors report 1 patient with severe pregnancy-induced hypertension treated with Prostacyclin. Patient 29 years old, previous pregnancy 2 times are complicated by hypertension. The first child because of intrauterine growth retardation Caesarean section, the second pregnancy 14 weeks missed abortion. Two gestational blood pressure is normal. The third pregnancy, blood pressure 130 / 80mmHg at 10 weeks of pregnancy, blood pressure rose to 150 / 90mmHg at 22 weeks of gestation, given methyldopa treatment, the gradual increase of 0.75g / day dose, protein appeared in the twenty-sixth week of pregnancy Urine, the twenty-seventh week Methyl Dopa dose increased to 3g / day blood pressure can not be controlled, plus serving hydralazide, dose added to 150mg / day still can not control blood pressure. Prostacyclin was given intravenously at a starting dose of 8 μg / kg / min due to ineffective conventional antihypertensive drugs, with an unexpectedly significant drop in blood pressure and a drop in diastolic blood pressure from 140 mmHg