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常规抗菌素治疗革兰氏阴性细菌引起的休克仅有5O％左右的成功率。这一部分是由于死亡的细菌释放出一种稳定而有高度毒性的脂多糖(LPS,内毒素)。LPS 由于网状内皮系统不能充分消除而持久存在于病人血循环中,最后导致血管虚脱,播散性血管内凝血,肾衰竭,休克肺和死亡。直接针对LPS 的特异性抗体已成功地减少了一些动物和人的脓毒性休克的死亡率。
Conventional antibiotic treatment of Gram-negative bacteria caused shock only about 50% success rate. This is due in part to the death of bacteria that release a stable and highly toxic lipopolysaccharide (LPS, endotoxin). LPS persists in the patient’s circulatory system due to inadequate reticuloendothelial system elimination, eventually leading to collapse of the blood vessels, disseminated intravascular coagulation, renal failure, shock lungs, and death. Specific antibodies directed against LPS have succeeded in reducing the mortality of septic shock in some animals and humans.