【摘 要】
:
Objective: To assess the relationship between yogurt intake and mortality risk from prospective cohort studies.Methods: The PubMed,EMBASE,and Web of Science databases were searched for all records related to yogurt intake and mortality risk[all-cause or c
【机 构】
:
Research Institute of Health Development Strategies, Fudan University, Shanghai 200032 , China;Schoo
论文部分内容阅读
Objective: To assess the relationship between yogurt intake and mortality risk from prospective cohort studies.Methods: The PubMed,EMBASE,and Web of Science databases were searched for all records related to yogurt intake and mortality risk[all-cause or cardiovascular disease (CVD) or cancer mortality]before October 1,2018.The Newcastle-Ottawa Quality Scale was used to estimate the quality of all eligible articles.The results of the highest and lowest categories of yogurt intake in each study were collected and the effect size was pooled using a random effects model.The dose-response analysis was calculated using the generalized least squares trend estimation model.Results: Eight eligible cohort studies were included in this meta-analysis.There were 235,676 participants in the 8 studies,and the number of deaths was 14,831.Compared with the lowest category,the highest category of yogurt intake was not significantly related with all-cause mortality[hazard ratio (HR)=0.93;95% confidence interval (CI): 0.85,1.01],CVD mortality (HR=0.92;95% CI: 0.81,1.03) and cancer mortality (HR=0.97;95% CI: 0.83,1.12).These studies were homogenous,since the homogeneity test showed that I2 was 28.7%,15.1% and 11.8%,respectively.However,yogurt intake ≥200 g/d was significantly associated with a lower all-cause mortality (HR=0.88;95% CI: 0.80,0.96) and CVD mortality (HR=0.87;95% CI: 0.77,0.99) in the subgroup analysis.The dose-response analysis showed that yogurt intake of 200 g/d was inversely associated with all-cause mortality (P=0.041,HR=0.95,95% CI: 0.92,1.00) and CVD mortality (P=0.009,HR=0.92,95% CI: 0.86,0.98),and all of which were linear relationship (P>0.05).Conclusions: This review provided the evidence regarding yogurt intake can reduce all-cause and CVD mortality.Although some positive findings were identified,more high-quality cohort studies and randomized controlled trials are warranted on a possible protective effect of yoghurt on health.
其他文献
Objective:To investigate the effects of Shengmai Injection (生脉注射液,SMI) on the proliferation,apoptosis and N-myc downstream-regulated gene 2 (NDRG2,a tumour suppressor gene) expression in varying densities of human hepatic stellate cells LX-2.Methods:LX-2
Objective:To observe the effects of electroacupuncture (EA) on reproductive outcomes in women with Shen (Kidndy) deficiency syndrome after in vitro fertilization-embryo transfer (IVF-ET),and explore the underlying molecular mechanism.Methods:Sixty-six inf
Objective:To evaluate the efficacy and safety of essential oil treatment for type Ⅲ chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).Methods:A randomized controlled trial was conducted from December 2014 to October 2015.Seventy type Ⅲ CP/CPPS pa
Objective:To investigate the effects of Ganoderma lucidum polysaccharides (GL-PS) on human fibroblasts and skin wound healing in Kunming male mice and to explore the putative molecular mechanism.Methods:Primary human skin fibroblasts were cultured.The via
Objective:To investigate the potential mechanisms that curcumin reverses 5-fluorouracil (5-FU) multidrug resistance (MDR).Methods:Cell growth and the inhibitory rate of curcumin (2-25 μ g/mL) and/or 5-FU (0.05-1000 μ g/mL) on human colon cancer HCT-8 and
Objective: To investigate the effect of a modi?ed Wuzi Yanzong Pill (五子衍宗丸, WZYZP) on the male rats\' testis after microwave radiation, as well as its potential mechanism. Methods: Forty-?ve male rats were randomly assigned to three groups: the control
Objective:To investigate the potential efficacy of panaxadiol saponins component (PDS-C) in the treatment of aplastic anemia (AA) model mice.Methods:Totally 70 mice were divided into 7 groups as follows:normal,model,low-,medium-,high-dose PDS-C (20,40,80
Objective:To investigate the mechanism of Chinese herbal medicine Dioscorea nipponica for the treatment of monosodium urate crystals-induced gouty arthritis (GA) in rats.Methods:Sixty male Wistar rats were divided into 6 groups:normal,model,indomethacin a
In order to solve the problem of long-term (>9 months) efficacy in the treatment of Alzheimer\'s disease (AD) by conventional therapy (CT),a staged and multiply-targeted sequential therapy based on the evolvement of pattems (STEP) was developed.Its main
As an interdisciplinary subject of medicine and artificial intelligence,intelligent diagnosis and treatment has received extensive attention.The standardization of Chinese medicine (CM) diagnosis has been always a bottleneck in the modernization and globa