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目的观察喜炎平注射液治疗小儿秋季腹泻的疗效和临床应用安全性。方法将年龄在4个月～3岁,病程≤2 d,具有典型症状的50例秋季腹泻患儿随机分为治疗组和对照组各25例,两组均给予液体疗法同时给予口服思密达,微生态制剂,饮食指导等常规治疗。此外,对照组加用病毒唑10 mg/(kg.d)静脉滴注治疗,治疗组加用喜炎平5mg/(kg.d)静脉滴注治疗,共3 d。对比分析两组治疗效果。结果①两组在退热、止吐和止泻等主要症状所需时间比较,差异均有统计学意义,治疗组明显短于对照组(P<0.05或P<0.01)。②治疗组的显效率为52%,显著优于对照组的显效率16%(P<0.01)。不良反应发生率低,偶见皮疹,对血小板及白细胞无影响。结论喜炎平治疗秋季腹泻安全有效,能快速改善秋季腹泻急性期症状,值得在临床推广。
Objective To observe the efficacy and clinical safety of Xiyanping injection in treating pediatric autumn diarrhea. Methods A total of 50 children with autumnal diarrhea, aged from 4 months to 3 years and with a duration of 2 days or less, were randomly divided into treatment group (n = 25) and control group (n = 25). Patients in both groups were given liquid therapy with oral Smecta , Probiotics, diet guidance and other routine treatment. In addition, the control group plus ribavirin 10 mg / (kg.d) intravenous infusion of the treatment group with Xiyanping 5mg / (kg.d) intravenous infusion for 3 d. Comparative analysis of two groups of treatment. Results ① There was significant difference between the two groups in the time required for the main symptoms such as fever, antiemetic and antidiarrheal. The treatment group was significantly shorter than the control group (P <0.05 or P <0.01). ② The effective rate of the treatment group was 52%, which was significantly better than that of the control group (16%, P <0.01). The incidence of adverse reactions is low, occasionally rash, no effect on platelets and white blood cells. Conclusion Xiyanping safe and effective treatment of autumn diarrhea, can quickly improve the symptoms of autumn diarrhea acute phase, it is worth in the clinical promotion.