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用特异性抗心房肽血清进行免疫组织化学研究表明丘脑下部,垂体和脑桥有心房肽免疫活性神经元。在正中隆起、嗅球和垂体腺发现有心房肽的特异性结合位点。因此心房肽有可能做为一种中枢递质或介质参与调节内环境稳定。作者对10名健康成年志愿者静脉灌注心房肽后血浆中五种垂体激素的浓度变化进行了研究。受试者于实验前2小时禁食,定量饮水,1小时后收集尿液一次。将低压冻干的心房肽500μg溶于5ml生理盐水中。以0.1μg/kg/min速度持续灌注心房肽20分钟,对照组以同样速度灌注生理盐水。连续记录血压和心率。2小时后
Immunohistochemical studies with specific anti-atrial-peptide serum showed atrial peptide immunoreactive neurons in the hypothalamus, pituitary and pons. Uplift in the middle, the olfactory bulb and pituitary gland found to have a specific binding site of atrial peptide. Therefore, atrial natriuretic peptide may serve as a central transmitter or mediator involved in the regulation of the internal environment stability. The authors studied the changes in the concentrations of five pituitary hormones in 10 healthy adult volunteers after intravenous infusion of atrial natriuretic peptide. Subjects were fasting 2 hours prior to the experiment, drinking water quantitatively, and collecting the urine one hour later. Lyophilized atrial natriuretic peptide 500 μg was dissolved in 5 ml of normal saline. Atrial natriuretic peptide was continuously infused at a rate of 0.1 μg / kg / min for 20 minutes and the control group was infused with normal saline at the same rate. Continuous recording of blood pressure and heart rate. 2 hours later