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本文报道我所研制的复方氟脲嘧啶治疗中晚期胃癌的初步结果。全组26例,其中资料完整可供分析者15例,皆经病理证实为胃腺癌。每日口服复方5-Fu300mg(胶囊中尚含甘草、陈皮、鲨肝醇等药),10g 为一疗程。结果部分缓解2例(13.3%),稳定13例(86.6%)。中数缓解期4.5月。本疗法消化道副反应轻微,骨髓抑制不明显,对免疫功能影响小,多数病例治疗后血清碱性磷酸酶有所下降。作者认为,本方案对晚期胃癌之稳定病情、缓解症状以及作为胃癌术后辅助治疗有一定作用。
This article reports the preliminary results of compound fluorouracil developed in the treatment of advanced gastric cancer. There were 26 cases in the whole group, of which 15 cases were completely available for analysis. All of them were pathologically confirmed as gastric adenocarcinoma. Daily oral compound 5-Fu 300mg (capsules still contain licorice, orange peel, shark liver alcohol and other drugs), 10g for a course of treatment. The results were partially relieved in 2 patients (13.3%) and stable in 13 patients (86.6%). The median remission period is 4.5 months. In this therapy, the side effects of the digestive tract were mild, bone marrow suppression was not obvious, and the immune function was little affected. In most cases, serum alkaline phosphatase was reduced after treatment. The authors believe that this program has a certain effect on the stable condition of advanced gastric cancer, relieve symptoms, and as an adjuvant treatment for gastric cancer.