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目的：探讨大肠癌患者癌细胞 Ｄ Ｎ Ａ 含量、倍体分布与体内胃泌素（ Ｇ）、生长抑素（ Ｓ Ｓ）水平变化，以及肿瘤临床病理参数之间的关系。方法：以图像分析法测定４０ 例大肠癌患者癌细胞 Ｄ Ｎ Ａ 含量及二倍体偏离指数（２ｃ Ｄ Ｉ）；放免法测定血清 Ｇ，血浆、肿瘤、癌近旁粘膜和癌远旁粘膜的 Ｓ Ｓ水平；借助计算机以多因素逐步回归法分析癌细胞 Ｄ Ｎ Ａ 含量、２ｃ Ｄ Ｉ、上述胃肠激素水平与肿瘤临床病理特点之间的关系。结果：肿瘤 Ｓ Ｓ上升伴随着 Ｄ Ｎ Ａ 含量和２ｃ Ｄ Ｉ显著下降（ Ｐ＜ ０．０１）；癌近旁粘膜 Ｓ Ｓ与 Ｄ Ｎ Ａ 含量（ Ｐ＜ ０．０５）和２ｃ Ｄ Ｉ（ Ｐ＜ ０．０１）呈显著正相关；直肠癌细胞 Ｄ Ｎ Ａ 含量和２ｃ Ｄ Ｉ明显增高（ Ｐ＜ ０．０１）。结论：内源性 Ｓ Ｓ参与了对癌细胞 Ｄ Ｎ Ａ 合成的调节；提高肿瘤和癌近旁粘膜 Ｓ Ｓ水平将有助于抑制大肠癌细胞内 Ｄ Ｎ Ａ 的合成。
OBJECTIVE: To investigate the relationship between the D N A content, ploidy distribution and gastrin (G) and somatostatin (S S) levels in colorectal cancer patients, as well as the clinicopathological parameters of the tumors. Methods: Image analysis was used to determine the D N A content in cancer cells and the diploid deviation index (2c D I) in 40 patients with colorectal cancer. Radioimmunoassay was used to determine serum G, plasma, tumor, adjacent mucosa of cancer, and distal mucosa of cancer. S level; using computer multi-factor stepwise regression analysis of the relationship between cancer cell D N A content, 2c D I, the above-mentioned gastrointestinal hormone levels and the clinicopathological features of the tumor. Results: The increase in tumor S S was accompanied by a significant decrease in D N A content and 2c D I (P< 0.01); S S and D N A levels in the proximal mucosa of cancer (P< 0.05) and 2c D I (P< 0.01) showed a significant positive correlation; the D N A content and 2c D I of rectal cancer cells were significantly higher (P < 0.01). CONCLUSIONS: Endogenous S S is involved in the regulation of D N A synthesis in cancer cells; increasing S S levels in tumors and adjacent mucosa of cancers will help inhibit the synthesis of D N A in colorectal cancer cells.