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琥珀胆硷是临床常用的肌松药,自1958年报道烧伤病人注射琥珀胆硷发生心律失常和心跳骤停后’至1967年后才证实烧伤、创伤、破伤风、神经肌肉疾病、尿毒症、严重感染等病人在疾病过程中注射琥珀胆硷后有血钾升高的潜在危险,重者足以引起心脏意外,危及生命。已引起麻醉界重视,现就琥珀胆硷与高血钾有关问题综述如下: 一、琥珀胆硷引起高血钾的机制: Gronert等的实验,比较了正常的、废用性肌萎缩、截瘫和去神经的狗的横纹肌,在注射琥珀胆硷(0.25mg/kg)后钾外溢的情况,证明去神经肌肉的钾外溢量最大,截瘫的略低,而废用性肌萎缩的略高于正常。说明有些疾病对琥珀胆硷有高度敏感,易引起血钾上升。 (一)正常肌肉对化学敏感的受体区是
Succinic choline is a commonly used clinical muscle relaxant. It has been reported since 1958 that patients with burned patients undergo systemic arrhythmia and cardiac arrest after injection of succinylcholine. Until 1967, burns, trauma, tetanus, neuromuscular diseases, uremia, Serious infection and other patients in the course of the disease after the injection of succinylcholine has the potential risk of elevated serum potassium, severe enough to cause heart accidents, life-threatening. Has caused the anesthesia community attention, are on the succinylcholine and hyperkalemia related issues are summarized as follows: First, the mechanism of high potassium chloride caused by succinylcholine: Gronert and other experiments, compared the normal, disuse atrophy, paraplegia and Strikethrough of denervated dogs, with potassium spillover after injection of succinylcholine (0.25 mg / kg), demonstrated the highest amount of potassium extirpation to denervated muscle, slightly lower paraplegia, and slightly higher than normal for detrusor atrophy . Description of some diseases are highly sensitive to succinylcholine, easily lead to elevated potassium. (A) The normal muscle is chemically sensitive to the receptor region