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目的分析血清中人附睾蛋白4(HE4)、碳水化合物抗原(CA125、CA199)、癌胚抗原(CEA)等血清肿瘤标志物联合检测对卵巢癌的诊断价值。方法选取安阳市肿瘤医院2013年11月—2015年10月收治的卵巢癌患者34例为观察组,选取本院同期卵巢良性肿瘤患者36例为对照组甲,选取本院同期进行健康体检的志愿者35例为对照组乙。比较3组受检者HE4、CA125、CA199、CEA水平及不同检测项目阳性率。结果观察组血清中HE4、CA125、CA199、CEA水平高于对照组甲和对照组乙,差异有统计学意义(P<0.05);对照组甲HE4、CA125、CA199、CEA水平高于对照组乙,差异有统计学意义(P<0.05)。检测HE4+CA125、HE4+CA125+CEA、HE4+CA125+CA199阳性率高于单一指标检测,差异有统计学意义(P<0.05);检测HE4+CA125+CA199+CEA阳性率高于其他组合检测,差异有统计学意义(P<0.05)。结论血清肿瘤标志物HE4、CA125、CA199及CEA联合检测能有效提高卵巢癌的检出率。
Objective To analyze the diagnostic value of serum tumor markers such as human epididymal protein 4 (HE4), carbohydrate antigen (CA125, CA199) and carcinoembryonic antigen (CEA) in the diagnosis of ovarian cancer. Methods 34 patients with ovarian cancer who were treated in Anyang Tumor Hospital from November 2013 to October 2015 were selected as the observation group and 36 patients with benign ovarian tumor in the same period of the hospital were selected as control group A. The volunteers 35 cases for the control group B. The HE 4, CA125, CA199, CEA levels and the positive rates of different test items in 3 groups were compared. Results The levels of HE4, CA125, CA199 and CEA in the observation group were significantly higher than those in the control group A and the control group B (P <0.05). The levels of HE4, CA125, CA199 and CEA in the control group were higher than those in the control group B , The difference was statistically significant (P <0.05). The positive rates of HE4 + CA125, HE4 + CA125 + CEA and HE4 + CA125 + CA199 were higher than those of single indicators (P <0.05), and the positive rates of HE4 + CA125 + CA199 + CEA were higher than those of other combinations , The difference was statistically significant (P <0.05). Conclusion Combined detection of serum tumor markers HE4, CA125, CA199 and CEA can effectively improve the detection rate of ovarian cancer.