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[背景]对邻苯二甲酸酯的环境暴露随时都有可能发生,研究表明它与一系列健康终点相关,包括不良出生结局。其中一些结局可以通过氧化应激介导,可能是邻苯二甲酸酯的一个作用机制。[目的]研究怀孕期间多个时间点的尿液样本中邻苯二甲酸酯代谢物与氧化应激生物标志之间的关联。[方法]研究对象是一个早产巢式病例对照研究中的妇女(病例n=130;对照n=352)。每位妇女都是在怀孕早期招募的,并随访直至分娩,提供的尿液样本最多有4次。测量9个邻苯二甲酸酯代谢物以估计暴露,并测定尿中的8-羟基脱氧鸟苷和8-异前列腺素作为氧化应激标志。采用线性混合模型评估个体内的相关性,模型中采用基于个体状态的选择概率的倒数作为权重,以使结果更具普遍性。[结果]邻苯二甲酸酯代谢物的四分位数间距增加与两种生物标志的浓度升高呈显著性相关。与二(2-乙基己基)邻苯二甲酸酯(DEHP)的代谢物相比较,与单苄基邻苯二甲酸酯(MBz P)、单-正丁基邻苯二甲酸酯(MBP)及单异邻苯二甲酸酯(Mi BP)相关性估计值的差异更大。[结论]在本文所研究的孕妇人群中,尿邻苯二甲酸酯代谢物与氧化应激生物标志的增加有关。对于把邻苯二甲酸酯暴露与出生结局联系在一起的研究来说,这些关联可能特别重要。虽然还需要在其他人群中复制这些结果,但它们对于一系列与邻苯二甲酸酯相关联的其他健康结局来说也是非常重要的。
BACKGROUND [0002] Environmental exposure to phthalates may occur at any time, and studies show that it is associated with a range of healthy endpoints, including poor birth outcomes. Some of these outcomes can be mediated by oxidative stress and may be a mechanism of action of phthalates. [Objective] To study the correlation between phthalate metabolites and oxidative stress biomarkers in urinal samples at multiple time points during pregnancy. [Method] The subjects were women in a premature nested case-control study (n = 130; n = 352). Every woman is recruited early in pregnancy and is followed up until childbirth, providing up to 4 urine samples. Nine phthalate metabolites were measured to estimate exposure, and 8-hydroxydeoxyguanosine and 8-isoprostane in urine were measured as markers of oxidative stress. A linear mixed model is used to assess the correlation in individuals, and the reciprocal of selection probability based on individual states is used as a weight in the model to make the result more universal. [Result] The interquartile range of phthalate metabolites increased significantly with the concentration of two biomarkers. Compared with the metabolites of bis (2-ethylhexyl) phthalate (DEHP), the molar ratio of MBP to monobenzyl phthalate (MBzP), mono-n-butyl phthalate ) And monoisophthalate (Mi BP) correlations. [Conclusion] Among the pregnant women studied in this paper, the urine phthalate metabolites are related to the increase of biomarkers of oxidative stress. These associations may be particularly important for studies that relate phthalate exposure to birth outcomes. Although these results also need to be replicated in other populations, they are also important for a range of other health outcomes associated with phthalates.