慢性阻塞性肺疾病(COPD)是一种具有气流受限特征的可以预防和治疗的疾病,气流受限不完全可逆、呈进行性发展,与肺部对香烟烟雾等有害气体或有害颗粒的异常炎症反应有关[1]。在世界范围内COPD的发病率和病死率都很高,并导致重大且持续增长的经济和社会学压力[2]。据估计,至2020年COPD将位居世界疾病经济负担的第3位,近期 Chronic Obstructive Pulmonary Disease (COPD) is a preventable and treatable disease characterized by limited air flow, with limited and limited airflow limitation, progressive development, and abnormal lung and toxins such as cigarette smoke and noxious particles Inflammatory response [1]. The worldwide incidence and mortality of COPD are high and lead to significant and sustained economic and societal stress [2]. It is estimated that by 2020, COPD will rank the third in the world in economic burden of disease, recently