OBJECTIVE To know the potency of Urena lobataleaves extract on the vasculopathy inhibition of diabetic rats.METHODS This study used control group post test only with male Sprague dawley rats.Diabetic rats were induced by high fructose diet(HFD)and single dose streptozotocin 25mg·kg-1 bw intra peritoneal.The rat was administrated orally with water extract of U.lobataleaves in dose of 250,500and1000mg·kg-1 bw for 4 weeks.After scarifying,blood sample were collected and then superoxyde dismutase(SOD)serum level,malondialdehyda(MDA),tumor necrosis factor-alpha(TNF-α)and circulating endothelial cells(CECs)were examined.The data was analyzed using ANOVA test continued with LSD test(P<0.05).RESULTS The oral administration of U.lobataleaves extract 250,500 and 1000mg·kg-1 bw were able to increase SOD serum level about 40%,70% and 100%respectively compared to diabetic group(P<0.05),while the MDA serum level was decreased by 20%,40%and 50%(P<0.05)respectively.The supplementation of water extract from U.lobatain dose of 250,500 and 1000mg·kg-1 bw also decrease TNF-αserum level approximately 40%,60% and 80% compared to control group(P<0.05),whereas the CECs level was decreased by 30%,50% and 70%(P<0.05)respectively.In diabetic groups,SOD serum level was decreased compared to normal group(P<0.05)while the MDA,TNF-αand CECs were increased(P<0.05).CONCLUSION U.lobata leaves extract could inhibit vasculopathy on diabetic rats by increasing of SOD serum level,decreasing of MDA serum level,TNF-αand CECs.This potency may be related to active substances which act as an anti-inflammatory and antioxidant in U.lobata extract. OBJECTIVE To know the potency of Urena lobataleaves extract on the vasculopathy inhibition of diabetic rats. METHODS This study used control group post test only with male Sprague Dawley rats. Diabetic rats were induced by high fructose diet (HFD) and single dose streptozotocin 25 mg · kg -1 bw intra peritoneal. The rat was administered orally with water extract of U.lobataleaves in dose of 250,500 and 1000 mg · kg -1 bw for 4 weeks. After scarifying, blood sample were collected and then superoxyde dismutase (SOD) serum level, malondialdehyda (MDA), tumor necrosis factor-alpha (TNF-α) and circulating endothelial cells (CECs) were measured.The data was analyzed using ANOVA test continued with LSD test (P <0.05) .RESULTS The oral administration of U.lobataleaves extract At 250 and 1000 mg · kg -1 bw were able to increase SOD serum level about 40%, 70% and 100% respectively compared to diabetic group (P <0.05), while the MDA serum level was decreased by 20%, 40% and 50 % (P <0.05) respectively. The supplementation of water ext ract from U. lobatain dose of 250, 500 and 1000 mg · kg -1 bw also decreased TNF-α serum level approximately 40%, 60% and 80% compared to control group (P <0.05), while the CEC level was decreased by 30% (P <0.05), while MDA and TNF-αand CECs were increased (P <0.05) .CONCLUSION U.lobata leaves extract could inhibit vasculopathy on diabetic rats by increasing of SOD serum level, decreasing of MDA serum level, TNF-α and CECs. This potency may be related to active substances which act as an anti-inflammatory and antioxidant in U. lobata extract.