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在慢性肝病中进行性纤维化与细胞外基质蛋白降解和合成的改变有关,因此肝纤维化是一个动态过程。临床上已有血清标志用于评估肝纤维生成和肝纤维化。然而,为了更好地了解肝纤维化过程的病理生理,需要非侵入性、可靠且敏感的标志物来评估正在进行的纤维溶解。基质金属蛋白酶(MMPs)是细胞外基质蛋白的主要的降解酶,在病理生理状态的组织重构和修复中起着重要的作用。MMPs是以无活动性的前酶形式分泌的,然后在细胞外间隙受激活,因此可在循环血液中被检测到。金属蛋白酶-3(MMP-3)有广泛的底物特异性,且能激活其他前金属蛋白酶。
Progressive fibrosis in chronic liver disease is associated with changes in extracellular matrix protein degradation and synthesis, and thus liver fibrosis is a dynamic process. Serum markers have been clinically used to assess liver fibrosis and liver fibrosis. However, in order to better understand the pathophysiology of liver fibrosis, non-invasive, reliable and sensitive markers are needed to assess ongoing fibrinolysis. Matrix metalloproteinases (MMPs) are the major degradation enzymes of extracellular matrix proteins and play an important role in the tissue remodeling and repair of pathophysiological states. MMPs are secreted as inactive proenzymes and are then activated in the extracellular space and can therefore be detected in circulating blood. Metalloproteinase-3 (MMP-3) has a broad substrate specificity and activates other pre-metalloproteases.