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原发性肝癌在恶性肿瘤中全球发病率居第五位,死亡率排第三位。过去已明确其病因与病毒性肝炎、肝硬化、黄曲霉毒素、化学致癌物、遗传易患性等相关。目前已发现肥胖是肝癌又一危险因素,瘦素参与肝癌的发生、发展,肝癌患者瘦素及其受体表达异常。该文就瘦素及其受体在原发性肝癌中的研究现状进行综述,旨在为临床肝癌诊治提供新方向。
The incidence of primary liver cancer in malignancy ranks fifth in the world, the third highest mortality. The past has clearly the etiology and viral hepatitis, cirrhosis, aflatoxins, chemical carcinogens, genetic predisposition and so on. It has been found that obesity is another risk factor for liver cancer, leptin involved in the occurrence and development of liver cancer, abnormal expression of leptin and its receptor in patients with liver cancer. This review summarizes the research status of leptin and its receptor in primary hepatocellular carcinoma (HCC) and aims to provide a new direction for the diagnosis and treatment of clinical liver cancer.