论文部分内容阅读
目的探讨syndecan-1在肝细胞癌(hepatocellular carcinoma,HCC)表达的临床病理意义,及其与肿瘤转移、增殖和血管生成的关系。方法用免疫组织化学染色检测了syndecan-1在30例HCC原发癌组织、癌旁组织和肝内转移灶的表达,血管内皮生长因子(vascularendothelial growth factor,VEGF)和CD34-微血管密度(microvessel density,MVD)在原发灶和肝内转移灶的表达,及Ki-67在原发灶的表达。结果与HCC癌旁组织相比,syndecan-1在原发癌组织表达水平明显增高,syndecan-1在肝内转移灶表达水平明显下降(χ2=25.62,P<0.001)。在HCC原发癌组织中,syndecan-1表达强度与Ki-67指数呈正相关(r=0.386,P<0.05)。在肝内转移灶中,syndecan-1表达强度与CD34-MVD呈正相关(r=0.370,P<0.05)。结论 HCC组织syndecan-1表达可能影响肿瘤转移、增殖和血管生成,提示syndecan-1在HCC生长和转移中的特殊作用可能为HCC有效治疗策略提供新思路。
Objective To investigate the clinicopathological significance of syndecan-1 expression in hepatocellular carcinoma (HCC) and its relationship with tumor metastasis, proliferation and angiogenesis. Methods The expression of syndecan-1 in 30 primary HCC tissues, adjacent non-cancerous tissues and intrahepatic metastases was detected by immunohistochemistry. The expressions of vascular endothelial growth factor (VEGF) and CD34-microvessel density , MVD) in primary and intrahepatic metastases, and the expression of Ki-67 in primary tumor. Results The expression of syndecan-1 in primary cancer tissues was significantly higher than that in adjacent non-cancerous tissues. The expression of syndecan-1 in liver metastases was significantly decreased (χ2 = 25.62, P <0.001). In primary HCC tissues, the expression of syndecan-1 was positively correlated with Ki-67 index (r = 0.386, P <0.05). In intrahepatic metastases, the intensity of syndecan-1 expression was positively correlated with CD34-MVD (r = 0.370, P <0.05). Conclusion The expression of syndecan-1 in HCC may affect tumor metastasis, proliferation and angiogenesis, suggesting that the special role of syndecan-1 in HCC growth and metastasis may provide new ideas for the effective treatment of HCC.