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由生物降解微球与免疫佐剂组成的口服抗原释放系统能够有效地保护抗原免受酶的降解.该系统通过增强M细胞对抗原的摄取而增强粘膜免疫应答.聚D,L-丙交酯-乙交酯聚合物(PLG)微球是一种十分有前途的微球载体,可用于携带粘膜抗原.磷酸胆碱(PC)是一种半抗原,存在于不同的致病菌(如肺炎球菌、伤寒杆菌、脑膜炎球菌)上.本研究将PC偶联在载体蛋白上,再用PLG微球加以包裹,由此制成经口免疫用负载微球,并观察其在小鼠中的粘膜免疫原性.
An oral antigen delivery system composed of biodegradable microspheres and an immunological adjuvant can effectively protect the antigen from degradation by the enzyme, which enhances the mucosal immune response by enhancing the uptake of antigen by M cells.Poly (D, L-lactide - Glycolide polymer (PLG) microspheres are a very promising microsphere carrier for mucosal antigens that are haptens present in different pathogenic bacteria (such as pneumonia Cocci, typhoid bacillus, meningococcus) in the present study, PC coupled to the carrier protein, and then wrapped with PLG microspheres, which made the microspheres for oral immunization, and observed in mice Mucosal immunogenicity.