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（目的）探讨血清胃泌素与大肠癌的关系及其临床意义。（方法）用放免法测定39例行根治术的大肠癌病人空腹血清胃泌素水平。（结果）大肠癌病人血清胃泌素水平明显高于对照组（P＜0.05）；高分化腺癌组术前血清胃泌素水平显著高于对照组及中、低分化腺癌组（P＜0.05），术后其鲁沙素水平明显下降（P＜0．05）；Dukes’A、B期术前血清胃泌素水平明显高于对照组及Dukes’C期组（P＜0．05），Dukes’A期病人根治术后其胃沙素水平较术前明显下降（P＜0．05）。（结论）血清胃泌素可能对大肠癌细胞有内分泌促生长作用；血清胃泌素水平测定可作为大肠癌诊断及预后判断的辅助指标，并可为选择大肠癌病人行激素治疗提供参考依据。
(Objective) To explore the relationship between serum gastrin and colorectal cancer and its clinical significance. (Methods) The fasting serum gastrin levels in 39 patients with colorectal cancer undergoing radical resection were measured by radioimmunoassay. (Results) Serum gastrin levels in patients with colorectal cancer were significantly higher than those in the control group (P<0.05); preoperative serum gastrin levels in the well-differentiated adenocarcinoma group were significantly higher than those in the control group and the poorly differentiated adenocarcinoma group (P< 0.05). After operation, the level of lussacin was significantly decreased (P<0.05); preoperative serum gastrin levels were significantly higher in Dukes’A and B stages than in the control group and Dukes’C stage group (P<0.05). ), The level of gassolin in the patients after Dukes’A phase surgery was significantly lower than before surgery (P<0.05). (Conclusion) Serum gastrin may have endocrine growth-promoting effect on colorectal cancer cells; determination of serum gastrin level may serve as an auxiliary indicator for the diagnosis and prognosis of colorectal cancer, and may provide a reference basis for selecting colorectal cancer patients for hormone therapy.